Ethnic differences in adiposity and diabetes risk – insights from genetic studies

Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of adiposity and body fat distribution in ethnic disparity in risk of type 2 diabetes. During the past decade, genome-wide association studies (GWAS) have identified more than 400 genetic variants associated with the risk of type 2 diabetes. The Eurocentric nature of these genetic studies have made them less effective in identifying mechanisms that make non-Europeans more susceptible to higher risk of disease. One possible mechanism suggested by epidemiological studies is the role of ethnic difference in body fat distribution. Using genetic variants associated with an ability to store extra fat in a safe place, which is subcutaneous adipose tissue, we discuss how different ethnic groups could be genetically less susceptible to type 2 diabetes by developing a more favourable fat distribution

Quadrature domains and kernel function zipping

It is proved that quadrature domains are ubiquitous in a very strong sense in the realm of smoothly bounded multiply connected domains in the plane. In fact, they are so dense that one might as well assume that any given smooth domain one is dealing with is a quadrature domain, and this allows access to a host of strong conditions on the classical kernel functions associated to the domain. Following this string of ideas leads to the discovery that the Bergman kernel can be zipped down to a strikingly small data set. It is also proved that the kernel functions associated to a quadrature domain must be algebraic.Comment: 13 pages, to appear in Arkiv for matemati

Further Evidence that the Redshifts of AGN Galaxies May Contain Intrinsic Components

In the decreasing intrinsic redshift (DIR) model galaxies are assumed to be born as compact objects that have been ejected with large intrinsic redshift components, z_(i), out of the nuclei of mature AGN galaxies. As young AGN (quasars) they are initially several magnitudes sub-luminous to mature galaxies but their luminosity gradually increases over 10^8 yrs, as z_(i) decreases and they evolve into mature AGN (Seyferts and radio galaxies). Evidence presented here that low- and intermediate-redshift AGN are unquestionably sub-luminous to radio galaxies is then strong support for this model and makes it likely that the high-redshift AGN (quasars) are also sub-luminous, having simply been pushed above the radio galaxies on a logz-m_(v) plot by the presence of a large intrinsic component in their redshifts. An increase in luminosity below z = 0.06 is also seen. It is associated in the DIR model with an increase in luminosity as the sources mature but, if real, is difficult to interpret in the cosmological redshift (CR) model since at this low redshift it is unlikely to be associated with a higher star formation rate or an increase in the material used to build galaxies. Whether it might be possible in the CR model to explain these results by selection effects is also examined.Comment: 12 pages, 2 figures. Contains response to referees suggestions. (Accepted for ApJL

Dominant mobility modulation by the electric field effect at the LaAlO_3 / SrTiO_3 interface

Caviglia et al. [Nature (London) 456, 624 (2008)] have found that the superconducting LaAlO_3 / SrTiO_3 interface can be gate modulated. A central issue is to determine the principal effect of the applied electric field. Using magnetotransport studies of a gated structure, we find that the mobility variation is almost five times as large as the sheet carrier density. Furthermore, superconductivity can be suppressed at both positive and negative gate bias. These results indicate that the relative disorder strength strongly increases across the superconductor-insulator transition.Comment: 4 pages, 4 figure

Implementation of the 64-meter-diameter Antennas at the Deep Space Stations in Australia and Spain

The management and construction aspects of the Overseas 64-m Antenna Project in which two 64-m antennas were constructed at the Tidbinbilla Deep Space Communications Complex in Australia, and at the Madrid Deep Space Communications Complex in Spain are described. With the completion of these antennas the Deep Space Network is equipped with three 64-m antennas spaced around the world to maintain continuous coverage of spacecraft operations. These antennas provide approximately a 7-db gain over the capabilities of the existing 26-m antenna nets. The report outlines the project organization and management, resource utilization, fabrication, quality assurance, and construction methods by which the project was successfully completed. Major problems and their solutions are described as well as recommendations for future projects

Construction of optimal witness for unknown two-qubit entanglement

Whether entanglement in a state can be detected, distilled, and quantified without full state reconstruction is a fundamental open problem. We demonstrate a new scheme encompassing these three tasks for arbitrary two-qubit entanglement, by constructing the optimal entanglement witness for polarization-entangled mixed-state photon pairs without full state reconstruction. With better efficiency than quantum state tomography, the entanglement is maximally distilled by newly developed tunable polarization filters, and quantified by the expectation value of the witness, which equals the concurrence. This scheme is extendible to multiqubit Greenberger-Horne-Zeilinger entanglement.Comment: Phys. Rev. Lett. 105, 230404 (2010); supplementary information (OWitness_sup.pdf) is included in source zip fil

Quantitying the Effects of Traffic Calming on Emissions Using on-road Measurement

The objective of this work was to determine the effect of one form of traffic calming on emissions. Traffic calming is aimed at reducing average vehicle speeds, especially in residential neighborhoods, often using physical road obstructions such as speed bumps, but it also results in a higher number of acceleration/deceleration events which in turn yield higher emissions. Testing was undertaken by driving a warmed-up Euro-1 spark ignition passenger car over a set of speed bumps on a level road, and then comparing the emissions output to a noncalmed level road negotiated smoothly at a similar average speed. For the emissions measurements, a novel method was utilized, whereby the vehicle was fitted with a portable Fourier Transform Infrared (FTIR) spectrometer, capable of measuring up to 51 different components in real-time on the road. The results showed that increases in emissions were much greater than was previously reported by other researchers using different techniques. When traffic-calmed results were compared to a smooth non-calmed road, there were substantial increases in CO2 (90%), CO (117%), NOx (195%) and THC (148%). These results form the basis for a good argument against traffic calming using speed bumps, especially for aggressive drivers. Slowing traffic down with speed restrictions enforced by speed cameras is a more environmentally friendly option

Evaluation of a FTIR Emission Measurement System for Legislated Emissions Using a SI Car

A series of chassis dynamometer test trials were conducted to assess the performance of a Fourier Transform Infra Red (FTIR) system developed for on-road vehicle exhaust emissions measurements. Trials used a EURO 1 emission compliant SI passenger car which, alongside the FTIR, was instrumented to allow the routine logging of engine speed, road speed, throttle position, air-fuel ratio, air flow and fuel flow in addition to engine, exhaust and catalyst temperatures. The chassis dynamometer facility incorporated an ‘industry standard’ measurement system comprising MEXA7400 gas analyzer and CVS bag sampling which was the ‘benchmark’ for the evaluation of FTIR legislated gas-phase emissions (CO, NOx, THC and CO2) measurements. Initial steady state measurements demonstrated strong correlations for CO, NOx and THC (R2 of 0.99, 0.97 0.99, respectively) and a good correlation for CO2 (R2 = 0.92). Subsequent transient and total mass emissions measurements from replicate samplings of four different driving cycles (two standard cycles, FTP75 and NEDC, and two novel cycles based on real-world data collected in Leeds) also show good response of FTIR and satisfied agreement between the FTIR and CVS bag sampling measurements. In general, the trial results demonstrate that the on-board FTIR emission measurement system provides reliable in-journey emissions data

Causality and Cirel'son bounds

An EPR-Bell type experiment carried out on an entangled quantum system can produce correlations stronger than allowed by local realistic theories. However there are correlations that are no-signaling and are more non local than the quantum correlations. Here we show that any correlations more non local than those achievable in an EPR-Bell type experiment necessarily allow -in the context of the quantum formalism- both for signaling and for generation of entanglement. We use our approach to rederive Cirel'son bound for the CHSH expression, and we derive a new Cirel'son type bound for qutrits. We discuss in detail the interpretation of our approach.Comment: 5 page